Drug General Information (ID: DDIDQ9G1MO)
Drug Name			Demeclocycline		Drug Info		Meticillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Demeclocycline-Meticillin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Demeclocycline				Meticillin
Mechanism		Bacteriostatic agent Change actively growing bacteria into static ones				Bactericidal agent Bactericidal activity requires bacterial growth
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Demeclocycline when combined with Meticillin

Recommended Action
Management		This combination should be avoided if possible.

References
1	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
2	Jawetz E "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med 123 (1975): 87-91
3	Olsson RA, Kirby JC, Romansky MJ "Pneumococcal meningitis in the adult." Ann Intern Med 55 (1961): 545-9