Details of Drug-Drug Interaction
| Drug General Information (ID: DDIDO4UWJ6) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ibutilide | Drug Info | Perflutren | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiarrhythmic Agents | Ultrasound Contrast Media | |||||||
| Structure | |||||||||
| Mechanism of Ibutilide-Perflutren Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ibutilide | Perflutren | |||||||
| Mechanism | Prolong QT interval | Prolong QT interval | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | QT interval | ||||||||
| Factor Description | Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is recommended if perflutren lipid microsphere suspension is used in combination with other drugs that can prolong the QT interval. Please refer to the prescribing information for these drugs for more information. No data are available regarding the effect of perflutren protein-type A microsphere suspension (Optison) on the QT interval of the electrocardiogram. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA. | ||||||||||||||||||
| 2 | Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO. | ||||||||||||||||||