Drug General Information (ID: DDIDN40VRK)
Drug Name			Naproxen		Drug Info		Rabeprazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nsaids/Analgesics				Antiulcer Agents
Structure

Mechanism of Naproxen-Rabeprazole Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Naproxen				Rabeprazole
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Naproxen due to altered gastric pH caused by Rabeprazole

Recommended Action
Management		Concomitant use of these drugs is generally not recommended.

References
1	Product Information. Naprosyn (naproxen). Syntex Laboratories Inc, Palo Alto, CA.