Drug General Information (ID: DDIDLT9M1Q)
Drug Name			Cefdinir		Drug Info		Ferrous gluconate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Iron Supplement
Structure

Mechanism of Cefdinir-Ferrous gluconate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Cefdinir				Ferrous gluconate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Ferrous gluconate due to formation of complexes caused by Cefdinir

Recommended Action
Management		To minimize potential interaction with iron, the product labeling recommends that cefdinir be taken at least 2 hours before or 2 hours after administration of iron-containing products. However, this separation time may not be sufficient to prevent the interaction when sustained-release iron products are used, especially in higher dosages. Patients should be advised that reddish stools may occur due to formation of a nonabsorbable complex between cefdinir or its breakdown products and iron in the gastrointestinal tract.

References
1	Product Information. Omnicef (cefdinir). Parke-Davis, Morris Plains, NJ.
2	Ueno K, Tanaka K, Tsujimura K, Morishima Y, Iwashige H, Yamazaki K, Nakata I "Impairment of cefdinir absorption by iron ion." Clin Pharmacol Ther 54 (1993): 473-5. [PMID: 8222489]