Drug General Information (ID: DDIDKS0638)
Drug Name			Octasulfur (topical)		Drug Info		Trifarotene (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Minerals And Electrolytes				Topical Acne Agents
Structure

Mechanism of Octasulfur (topical)-Trifarotene (topical) Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Octasulfur (topical)				Trifarotene (topical)
Mechanism		Local skin irritation/drying				Local skin irritation/drying
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Octasulfur (topical) and Trifarotene (topical)

Recommended Action
Management		Depending on circumstances (e.g., areas of application), concomitant use should preferably be avoided, and a rest period considered in between use of these products.

References
1	Product Information. Retin-A (tretinoin). Ortho Pharmaceutical Corporation, Raritan, NJ.
2	Product Information. Tazorac (tazarotene topical). Allergan Inc, Irvine, CA.