Drug General Information (ID: DDID6K71V4)
Drug Name			Ketoconazole		Drug Info		Mepenzolate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Parasympatholytics
Structure

Mechanism of Ketoconazole-Mepenzolate Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ketoconazole				Mepenzolate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ketoconazole due to altered gastric pH caused by Mepenzolate

Recommended Action
Management		Anticholinergic agents should be administered at least 2 hours after ketoconazole.

References
1	Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.