Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDID4GIBPA)
  Drug Name Lorazepam Drug Info Propranolol Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antianxiety Agents Antianxiety Agents
  Structure

 Mechanism of Lorazepam-Propranolol Interaction (Severity Level: Minor)
     Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Lorazepam Propranolol
      Mechanism 1 Benzodiazepines Inhibition metabolism of benzodiazepines
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Lorazepam caused by Propranolol 
      Mechanism 2 Benzodiazepine Inhibition metabolism of benzodiazepines
      Key Mechanism Factor 2
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Lorazepam caused by Propranolol 

References
1 Hawksworth G, Betts T, Crowe A, et al "Diazepam/beta-adrenoceptor antagonist interactions." Br J Clin Pharmacol 17 Suppl 1 (1984): s69-76. [PMID: 6146341]
2 Klotz U, Reimann IW "Pharmacokinetic and pharmacodynamic interaction study of diazepam and metoprolol." Eur J Clin Pharmacol 26 (1984): 223-6. [PMID: 6723761]
3 Ochs HR, Greenblatt DJ, Locniskar A, Weinbrenner J "Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate." Klin Wochenschr 64 (1986): 1217-21. [PMID: 2879960]
4 Ochs HR, Greenblatt DJ, Verburg-Ochs B "Propranolol interactions with diazepam, lorazepam and alprazolam." Clin Pharmacol Ther 36 (1984): 451-5. [PMID: 6434219]
5 Scott AK, Cameron GA, Hawksworth GM "Interaction of metoprolol with lorazepam and bromazepam." Eur J Clin Pharmacol 40 (1991): 405-9. [PMID: 2050176]
6 Sonne J, Dossing M, Loft S, et al "Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol." Br J Clin Pharmacol 29 (1990): 33-7. [PMID: 2297460]