Drug General Information (ID: DDID1O9JBP)
Drug Name			Chloramphenicol		Drug Info		Ferrous gluconate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Iron Supplement
Structure

Mechanism of Chloramphenicol-Ferrous gluconate Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Chloramphenicol				Ferrous gluconate
Mechanism		Interference with the efficacy of iron or vitamin B12 in the treatment of anemia by inhibiting erythrocyte maturation				Iron oral
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Chloramphenicol when combined with Ferrous gluconate

Recommended Action
Management		Patients with preexisting anemia should preferably not receive chloramphenicol due to the drug's depressive effect on bone marrow and reticulocytes. If use is unavoidable, the lowest effective dosage of chloramphenicol should be given. Hematologic response to iron or vitamin B12 therapy should be closely monitored.

References
1	Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
2	Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
3	Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42