Drug General Information (ID: DDICHIGK3W)
Drug Name			Progesterone		Drug Info		Doxorubicin (liposomal)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Progesterone Receptor Modulators				Antineoplastics
Structure

Mechanism of Progesterone-Doxorubicin (liposomal) Interaction (Severity Level: Moderate)
Additive myelosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Progesterone				Doxorubicin (liposomal)
Mechanism		Increase the risk of doxorubicin-associated hematologic toxicity				Doxorubicin
Key Mechanism Factor 1
		Factor Name		Myelosuppressive effects
		Factor Description		Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia).
Mechanism Description		Additive myelosuppressive effects by the combination of Progesterone and Doxorubicin (liposomal)

Recommended Action
Management		It is advisable to monitor patients for neutropenia and thrombocytopenia during coadministration.

References
1	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
2	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
3	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."