Drug General Information (ID: DDICEHO3J6)
Drug Name			Ibutilide		Drug Info		Bretylium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiarrhythmic Agents
Structure

Mechanism of Ibutilide-Bretylium Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Ibutilide				Bretylium
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Ibutilide and Bretylium

Recommended Action
Management		Class III antiarrhythmic agents should not be given concomitantly with ibutilide (which also has class III properties) or within four hours after ibutilide is given.

References
1	Canadian Pharmacists Association.
2	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.