Drug General Information (ID: DDIC8MHJ7G)
Drug Name			Baclofen		Drug Info		Enflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Muscle Relaxants				Anesthetics
Structure

Mechanism of Baclofen-Enflurane Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Baclofen				Enflurane
Mechanism		Increase the risk of seizures and cardiovascular disturbances, and prolong the duration of anesthesia				General anesthetic
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Baclofen and Enflurane

Recommended Action
Management		Caution is recommended if general anesthetics are administered to patients who have been pretreated with, or are currently receiving intrathecal baclofen.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.