Drug General Information (ID: DDIBXIZ9JM)
Drug Name			Benzylpenicillin		Drug Info		Sarecycline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Tetracyclines
Structure

Mechanism of Benzylpenicillin-Sarecycline Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Benzylpenicillin				Sarecycline
Mechanism		Bactericidal agent Bactericidal activity requires bacterial growth				Bacteriostatic agent Change actively growing bacteria into static ones
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Benzylpenicillin when combined with Sarecycline

Recommended Action
Management		This combination should be avoided if possible.

References
1	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
2	Jawetz E "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med 123 (1975): 87-91
3	Olsson RA, Kirby JC, Romansky MJ "Pneumococcal meningitis in the adult." Ann Intern Med 55 (1961): 545-9