Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIBW5ZLNY)
Drug Name			Triamterene		Drug Info		Hydrocortisone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antiinflammatory Agents
Structure

Mechanism of Triamterene-Hydrocortisone Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph

Drug Name		Triamterene				Hydrocortisone
Mechanism		Antihypertensive agent Amiloride-sensitive sodium channel Blocker				Hypertensive effects Induction of sodium and fluid retention
Key Mechanism Factor 1
		Factor Name		Amiloride-sensitive sodium channel				Structure Sequence
		Protein Family		Amiloride-sensitive sodium channel (TC 1.A.6) family
		Protein Function		Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Click to Show/Hide
Mechanism Description		Antagonize the effect of Triamterene when combined with Hydrocortisone

Recommended Action
Management		Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.