Drug General Information (ID: DDIBPZLUQF)
Drug Name			Isosorbide dinitrate		Drug Info		Thallous Chloride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Isosorbide dinitrate-Thallous Chloride Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Isosorbide dinitrate				Thallous Chloride
Mechanism		Alter the myocardial uptake of thallous chloride				Thallous Chloride
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Thallous Chloride by Isosorbide dinitrate

Recommended Action
Management		Clinicians should be aware of possible diagnostic interference by these drugs.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Nuclear Pharmacy Website. University of Arkansas for Medical Sciences. College of Pharmacy "Drug - Radiopharmaceutical Interactions. Available from: URL: http://nuclearpharmacy.uams.edu/nicki.html#tl.".
3	Product Information. Thallous Chloride Tl 201 (thallous chloride Tl-201). GE Healthcare, Princeton, NJ.