Drug General Information (ID: DDIBPD1V6H)
Drug Name			Digoxin		Drug Info		Mepenzolate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Parasympatholytics
Structure

Mechanism of Digoxin-Mepenzolate Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Mepenzolate
Mechanism		Absorption is influenced by gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Digoxin due to GI dynamics variation caused by Mepenzolate

References
1	Binnion PF, McDermott M, LeSher D "Bioavailability of digoxin." Lancet 1 (1973): 1118. [PMID: 4122032]
2	Brown DD, Schmid J, Long RA, Hull JH "A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules." J Clin Pharmacol 25 (1985): 360-4. [PMID: 4031112]
3	Johnson BF, O'Grady J, Bye C "The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide." Br J Clin Pharmacol 5 (1978): 465-7. [PMID: 656287]
4	Manninen V, Apajalahti A, Simonen H, Reissell P "Effect of propantheline and metoclopramide on absorption of digoxin." Lancet 1 (1973): 1118-9. [PMID: 4122033]
5	Product Information. Lanoxicaps (digoxin). Glaxo Wellcome, Research Triangle Park, NC.