Drug General Information (ID: DDIBEO5NDS)
Drug Name			Acarbose		Drug Info		Metformin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiabetic Agents				Antidiabetic Agents
Structure

Mechanism of Acarbose-Metformin Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Acarbose				Metformin
Mechanism		Delayed intestinal absorption of metformin				Metformin
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Metformin due to GI dynamics variation caused by Acarbose

References
1	Scheen AJ, de Magalhaes AC, Salvatore T, Lefebvre PJ "Reduction of the acute bioavailability of metformin by the a-glucosidase inhibitor acarbose in normal man." Eur J Clin Invest 24 Suppl 3 (1994): 50-4. [PMID: 7818725]