Drug General Information (ID: DDIBD8Q290)
Drug Name			Liothyronine		Drug Info		Digitoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Hormone Replacement Agents				Antiarrhythmic Agents
Structure

Mechanism of Liothyronine-Digitoxin Interaction (Severity Level: Moderate)
Increased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Liothyronine				Digitoxin
Mechanism		Increased clearance or sensitivity of digitalis glycosides				Digitalis glycosides
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased renal excretion of Digitoxin caused by Liothyronine

Recommended Action
Management		Monitor the patient closely for altered efficacy and safety while achieving a euthyroid state or when thyroid hormones are added, discontinued, or dosing changes are made. Digitalis dose increases may be required.

References
1	Frye RL, Braunwald E "Studies on digitalis. III: The influence of triiodothyronine on digitalis requirements." Circulation 23 (1961): 376-82. [PMID: 13702336]
2	Huffman DH, Klaassen CD, Hartman CR "Digoxin in hyperthyroidism." Clin Pharmacol Ther 22 (1977): 533-8. [PMID: 913019]
3	Lawrence JR, Sumner DJ, Kalk WJ, et al "Digoxin kinetics in patients with thyroid dysfunction." Clin Pharmacol Ther 22 (1977): 7-13. [PMID: 872497]