Drug General Information (ID: DDIBAKQ0V5)
Drug Name			Gonadorelin		Drug Info		Ganirelix		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Fertility Agents				Abortifacient Agents
Structure

Mechanism of Gonadorelin-Ganirelix Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Gonadorelin				Ganirelix
Mechanism		Exogenous gonadotropins				Suppress the secretion of pituitary gonadotropins
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Gonadorelin when combined with Ganirelix

Recommended Action
Management		A dose adjustment may be necessary when exogenous gonadotropins are used during controlled ovarian hyperstimulation.

References
1	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. Antagon (ganirelix) Organon, West Orange, NJ.