| Management |
When used with atazanavir/cobicistat or atazanavir/ritonavir once daily in adults, the dosage of the H2-receptor antagonist should be no more than the equivalent of famotidine 40 mg twice daily in antiretroviral treatment-naive patients and 20 mg twice daily in treatment-experienced patients. Atazanavir/cobicistat or atazanavir/ritonavir should be administered simultaneously with, and/or at least 10 hours after, the H2-receptor antagonist. If tenofovir is also prescribed, no additional precaution is necessary in treatment-naive patients, whereas the dosage of atazanavir/ritonavir should be increased to 400 mg/100 mg once a day in treatment-experienced patients. All three antiretroviral agents should be administered as a single daily dose with food. In the event that ritonavir is not tolerated by a treatment-naive patient, atazanavir may be administered at an increased dosage of 400 mg once daily at least 2 hours before and at least 10 hours after the H2-receptor antagonist. |
