Drug General Information (ID: DDIB5E79VI)
Drug Name			Lindane		Drug Info		Peginterferon beta-1a		Drug Info
Drug Type		Small molecule				Interferons
Therapeutic Class		Antiscabies Agent				Interferons

Mechanism of Lindane-Peginterferon beta-1a Interaction (Severity Level: Moderate)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Lindane				Peginterferon beta-1a
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Lindane and Peginterferon beta-1a

Recommended Action
Management		Caution is advised if lindane is used with any substance that can reduce the seizure threshold, particularly in the very young or the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections). Lindane should be used according to recommended dosage and directions for application.

References
1	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
2	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
3	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]