Details of Drug-Drug Interaction
| Drug General Information (ID: DDIB4IZCXT) | |||||||||
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| Drug Name | Altretamine | Drug Info | Isocarboxazid | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antineoplastics | Antidepressants | |||||||
| Structure | |||||||||
| Mechanism of Altretamine-Isocarboxazid Interaction (Severity Level: Moderate) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Altretamine | Isocarboxazid | |||||||
| Mechanism | Hypotensive effects |
Hypotensive effects Monoamine oxidase non-selective Inhibitor |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Monoamine oxidase | Structure Sequence | |||||||
| Protein Family | Flavin monoamine oxidase family | ||||||||
| Protein Function |
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised if altretamine must be used with a MAOI or tricyclic antidepressant, particularly in elderly patients. All patients receiving the combination should be advised to avoid rising abruptly from a sitting or lying position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting. | ||||||||