Drug General Information (ID: DDIB02H8XC)
Drug Name			Lamivudine		Drug Info		Zalcitabine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Anti-Hiv Agents
Structure

Mechanism of Lamivudine-Zalcitabine Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Lamivudine				Zalcitabine
Mechanism 1		Prodrug activated by intracellular phosphorylation				Intracellular phosphorylation inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Lamivudine when combined with Zalcitabine
Mechanism 2		Intracellular phosphorylation inhibitor				Prodrug activated by intracellular phosphorylation
Key Mechanism Factor 2
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Zalcitabine when combined with Lamivudine

Recommended Action
Management		The use of the cytidine analog NRTIs lamivudine, emtricitabine, or zalcitabine in any combination in an antiretroviral treatment regimen that consists of two NRTIs is not recommended. Local antiretroviral treatment experts should be consulted for current practice.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Veal GJ, Hoggard PG, Barry MG, Khoo S, Back DJ "Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation." AIDS 10 (1996): 546-8.[PMID: 8724049]