Drug General Information (ID: DDIATI6FH8)
Drug Name			Interferon alfa-2b		Drug Info		Lurbinectedin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Alkylating Agents
Structure

Mechanism of Interferon alfa-2b-Lurbinectedin Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Interferon alfa-2b				Lurbinectedin
Mechanism		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Interferon alfa-2b and Lurbinectedin

Recommended Action
Management		Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.