Drug General Information (ID: DDIARFENSU)
Drug Name			Ziconotide		Drug Info		Lasmiditan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antimigraine Agents
Structure

Mechanism of Ziconotide-Lasmiditan Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ziconotide				Lasmiditan
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ziconotide and Lasmiditan

Recommended Action
Management		Caution is advised during coadministration of lasmiditan with alcohol, other CNS depressants, or other agents that cause sedation. Patients should be advised against driving and other activities that require complete mental alertness for at least 8 hours after lasmiditan is administered.

References
1	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.