Drug General Information (ID: DDIABQNZLC)
Drug Name			Grepafloxacin		Drug Info		Mercaptopurine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antineoplastics
Structure

Mechanism of Grepafloxacin-Mercaptopurine Interaction (Severity Level: Minor)
Altered intestinal mucosa Click to Show/Hide Mechanism Graph
Drug Name		Grepafloxacin				Mercaptopurine
Mechanism		Absorption affected by changes in intestinal mucosa				Alteration of intestinal mucosa
Key Mechanism Factor 1
		Factor Name		Intestinal mucosa
		Factor Description		Intestinal mucosal barrier function is the ability of the intestine to adequately contain microorganisms and molecules in the lumen while maintaining the ability to absorb nutrients. The absorption of drugs may be altered when the intestinal mucosa is disrupted.
Mechanism Description		Decreased absorption of Grepafloxacin due to intestinal mucosa variation caused by Mercaptopurine

References
1	Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]