Drug General Information (ID: DDIA91MU4J)
Drug Name			Octreotide		Drug Info		Telotristat ethyl		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Somatostatin/Somatostatin Analogs				Serotonin Synthesis Inhibitors
Structure

Mechanism of Octreotide-Telotristat ethyl Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Octreotide				Telotristat ethyl
Mechanism		Reduce pharmacological effects of telotristat ethyl				Telotristat ethyl
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Telotristat ethyl when combined with Octreotide

Recommended Action
Management		Short-acting octreotide should be administered at least 30 minutes after telotristat ethyl.

References
1	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
2	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
3	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.