Drug General Information (ID: DDIA8T5OVG)
Drug Name			Triamterene		Drug Info		Spironolactone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Diuretics
Structure

Mechanism of Triamterene-Spironolactone Interaction (Severity Level: Major)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Triamterene				Spironolactone
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Triamterene and Spironolactone

Recommended Action
Management		Given the potential for serious, sometimes fatal cardiac arrhythmias associated with hyperkalemia, the concurrent use of more than one potassium-sparing diuretic is considered contraindicated.

References
1	Product Information. Aldactone (spironolactone). Searle, Skokie, IL.
2	Product Information. Dyrenium (triamterene). SmithKline Beecham, Philadelphia, PA.
3	Product Information. Midamor (amiloride). Merck & Co, Inc, West Point, PA.