Drug General Information (ID: DDIA7BR452)
  Drug Name Torasemide Drug Info Enoxacin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Diuretics Antiinfective Agents
  Structure

 Mechanism of Torasemide-Enoxacin Interaction (Severity Level: Minor)
     Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Torasemide Enoxacin
      Mechanism Competitive inhibition of renal tubular secretion of quinolone Quinolone
      Key Mechanism Factor 1
Factor Name Renal tubular secretion
Factor Description Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
      Mechanism Description
  • Decreased elimination of Enoxacin caused by Torasemide mediated competitive inhibition of renal tubular secretion

References
1 Sudoh T, Fujimura A, Shiga T, Sasaki M, Harada K, Tateishi T, Ohashi K, Ebihara A "Renal clearance of lomefloxacin is decreased by furosemide." Eur J Clin Pharmacol 46 (1994): 267-9. [PMID: 8070509]