Drug General Information (ID: DDIA37JWSP)
Drug Name			Clonidine		Drug Info		Insulin detemir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antidiabetic Agents
Structure

Mechanism of Clonidine-Insulin detemir Interaction (Severity Level: Moderate)
Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Drug Name		Clonidine				Insulin detemir
Mechanism		Diminish the physiological response to hypoglycemia induced by antidiabetic agent				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Hypoglycemia
		Factor Description		Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
Mechanism Description		Increased risk of hypoglycemia by the combination of Clonidine and Insulin detemir

Recommended Action
Management		Patients should be instructed about the need for regular monitoring of blood glucose levels and be aware that certain symptoms of hypoglycemia such as tremors, sweating, and tachycardia may be reduced or absent during treatment with clonidine.

References
1	Product Information. NovoLog Mix 70/30 FlexPen (insulin aspart-insulin aspart protamine). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
2	Hedeland H, Dymling JF, Hokfelt B "The effect of insulin-induced hypoglycaemia on plasma renin activity and urinary catecholamines before and following clonidine (Catapresan) in man." Acta Endocrinol (Copenh) 71 (1972): 321-30
3	Product Information. Lantus (insulin glargine) Aventis Pharmaceuticals, Swiftwater, PA.