Drug General Information (ID: DDIA1E0V86)
Drug Name			Halothane		Drug Info		Aminophylline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Bronchodilators
Structure

Mechanism of Halothane-Aminophylline Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Halothane				Aminophylline
Mechanism		Increase the arrhythmogenic effects of catecholamines				Enhance the release of catecholamines
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Aminophylline and Halothane

Recommended Action
Management		This combination should be avoided if possible. Halothane may interact in a similar manner with other methylxanthines.

References
1	Roizen MF, Stevens WC "Multiform ventricular tachycardia due to the interaction of aminophylline and halothane." Anesth Analg 57 (1978): 738-41.[PMID: 570000]
2	Richards W, Thompson J, Lewis G, et al "Cardiac arrest associated with halothane anesthesia in a patient receiving theophylline." Ann Allergy 61 (1988): 83-4.[PMID: 3400904]