Details of Drug Interaction

Drug General Information (ID: DDI9Z630QJ)
Drug Name		Ipratropium (nasal)	Drug Info		Tiotropium	Drug Info
Drug Type	Small molecule			Small molecule
Therapeutic Class	Bronchodilators			Bronchodilators
Structure

Mechanism of Ipratropium (nasal)-Tiotropium Interaction (Severity Level: Minor)
Additive anticholinergic effects Click to Show/Hide Mechanism Graph

Drug Name	Ipratropium (nasal)		Tiotropium
Mechanism	Anticholinergic effects Muscarinic acetylcholine receptor Antagonist		Anticholinergic effects Muscarinic acetylcholine receptor Antagonist
Key Mechanism Factor 1
	Factor Name	Muscarinic acetylcholine receptor M		Structure Sequence
	Protein Family	G-protein coupled receptor 1 family
	Protein Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Click to Show/Hide
Mechanism Description	Additive anticholinergic effects by the combination of Ipratropium (nasal) and Tiotropium

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Atrovent nasal spray (ipratropium nasal). Boehringer-Ingelheim, Ridgefield, CT.
3	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.

Details of Drug-Drug Interaction