Drug General Information (ID: DDI9VEK03F)
Drug Name			Clozapine		Drug Info		Methimazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Antithyroid Agents
Structure

Mechanism of Clozapine-Methimazole Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Clozapine				Methimazole
Mechanism		Granulocytopenia				Granulocytopenia
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Clozapine and Methimazole

Recommended Action
Management		If these drugs must be used together, close observation and testing for evidence of granulocytopenia is recommended. Patients should be advised to promptly report any symptoms such as tiredness, weakness, sore throat, fever, stomatitis, malaise, or flu-like symptoms.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Rocco PL "Acute granulocytopenia in concomitant treatment of clozapine and methimazole." Postgrad Med J 70 (1994): 312-3.[PMID: 8183786]