Drug General Information (ID: DDI9VD4GFR)
Drug Name			Octreotide		Drug Info		Insulin aspart (aspart)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Somatostatin/Somatostatin Analogs				Antidiabetic Agents
Structure

Mechanism of Octreotide-Insulin aspart (aspart) Interaction (Severity Level: Moderate)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Octreotide				Insulin aspart (aspart)
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Insulin aspart (aspart) when combined with Octreotide
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Insulin aspart (aspart) when combined with Octreotide

Recommended Action
Management		Close monitoring of diabetic control is recommended if somatostatin analogs are prescribed to patients with preexisting diabetes. Glycemic status including fasting plasma glucose and/or hemoglobin A1c should be assessed prior to initiation of therapy and periodically during therapy in accordance with manufacturer's product labeling, and the antidiabetic treatment adjusted as necessary.

References
1	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
2	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
3	Williams G, Fuessl HS, Burrin JM, Chilvers E, Bloom SR "Postprandial glycaemic effects of a long-acting somatostatin analogue (octreotide) in non-insulin diabetes mellitus." Horm Metab Res 20 (1988): 168-70. [PMID: 2898427]