Drug General Information (ID: DDI9LWQTCF)
Drug Name			Bleomycin		Drug Info		Etoposide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antineoplastics
Structure

Mechanism of Bleomycin-Etoposide Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Bleomycin				Etoposide
Mechanism 1		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Bleomycin and Etoposide
Additive myelosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Bleomycin				Etoposide
Mechanism 2		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 2
		Factor Name		Myelosuppressive effects
		Factor Description		Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia).
Mechanism Description		Additive myelosuppressive effects by the combination of Bleomycin and Etoposide

Recommended Action
Management		Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
5	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
6	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
7	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
8	Product Information. Paraplatin (carboplatin). Bristol-Myers Squibb, Princeton, NJ.
9	Product Information. Zanosar (streptozocin). Pharmacia and Upjohn, Kalamazoo, MI.