Drug General Information (ID: DDI9LA3TGO)
Drug Name			Cyclosporine		Drug Info		Plazomicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Aminoglycosides//Antibiotics
Structure

Mechanism of Cyclosporine-Plazomicin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Plazomicin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Cyclosporine and Plazomicin

Recommended Action
Management		If these agents must be used concomitantly, renal function should be closely monitored.

References
1	Chandrasekar PH, Cronin SM "Nephrotoxicity in bone marrow transplant recipients receiving aminoglycoside plus cyclosporine or aminoglycoside alone." J Antimicrob Chemother 27 (1991): 845-9. [PMID: 1938691]
2	Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50. [PMID: 2683269]
3	Product Information. Arikayce (amikacin liposome). Insmed Incorporated, Bridgewater, NJ.
4	Product Information. Sandimmune (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
5	Termeer A, Hoitsma AJ, Koene RA "Severe nephrotoxicity caused by the combined use of gentamicin and cyclosporine in renal allograft recipients." Transplantation 42 (1986): 220-1. [PMID: 3526659]
6	Whiting PH, Simpson JG "The enhancement of cyclosporin A-induced nephrotoxicity by gentamicin." Biochem Pharmacol 32 (1983): 2025-8. [PMID: 6870931]