Drug General Information (ID: DDI8TCW6DR)
  Drug Name Enoxacin Drug Info Nizatidine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinfective Agents Antiulcer Agents
  Structure

 Mechanism of Enoxacin-Nizatidine Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Enoxacin Nizatidine
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Enoxacin due to altered gastric pH caused by Nizatidine 

References
1 Lebsack ME, Nix D, Ryerson B, et al "Effect of gastric acidity on enoxacin absorption." Clin Pharmacol Ther 52 (1992): 252-6. [PMID: 1526081]
2 Misiak PM, Eldon MA, Toothaker RD, Sedman AJ "Effects of oral cimetidine or ranitidine on the pharmacokinetics of intravenous enoxacin." J Clin Pharmacol 33 (1993): 53-6. [PMID: 8429114]