Drug General Information (ID: DDI8S3GVCK)
Drug Name			Atenolol		Drug Info		Ampicillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antibiotics
Structure

Mechanism of Atenolol-Ampicillin Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Atenolol				Ampicillin
Mechanism		Atenolol				Decrease the absorption of atenolol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Atenolol caused by Ampicillin

Recommended Action
Management		These results suggest that the interaction may be attenuated by dividing the ampicillin dosage into smaller, more frequent doses and/or staggering the times of administration of the two drugs.

References
1	McLean AJ, Tonkin A, McCarthy P, Harrison P "Dose-dependence of atenolol-ampicillin interaction." Br J Clin Pharmacol 18 (1984): 969-71. [PMID: 6529538]
2	Schafer-Korting M, Kirch W, Axthelm T, Kohler H, Mutschler E "Atenolol interaction with aspirin, allopurinol, and ampicillin." Clin Pharmacol Ther 33 (1983): 283-8. [PMID: 6825385]