Drug General Information (ID: DDI8PVSMRL)
Drug Name			Netilmicin		Drug Info		Carboplatin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antineoplastics
Structure

Mechanism of Netilmicin-Carboplatin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Netilmicin				Carboplatin
Mechanism 1		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Netilmicin and Carboplatin
Increased risk of ototoxicity Click to Show/Hide Mechanism Graph
Drug Name		Netilmicin				Carboplatin
Mechanism 2		Ototoxicity				Ototoxicity
Key Mechanism Factor 2
		Factor Name		Ototoxicity
		Factor Description		Ototoxicity is the damage to the organs of hearing and/or balance following exposure to drugs or chemicals that affect the inner ear. Ototoxic drugs can impair hearing, balance, or both.
Mechanism Description		Increased risk of ototoxicity by the combination of Netilmicin and Carboplatin

Recommended Action
Management		In patients currently receiving carboplatin therapy, the use of less toxic antimicrobials is preferable. If carboplatin and an aminoglycoside must be used together, renal function, auditory and vestibular function, and serum magnesium should be monitored carefully.

References
1	Product Information. Paraplatin (carboplatin). Bristol-Myers Squibb, Princeton, NJ.