Details of Drug-Drug Interaction
| Drug General Information (ID: DDI8647R9W) | |||||||||
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| Drug Name | Desmopressin | Drug Info | Phenylbutazone | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antidiuretic Hormones | Analgesics | |||||||
| Structure | |||||||||
| Mechanism of Desmopressin-Phenylbutazone Interaction (Severity Level: Moderate) | |||||||||
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| Increased risk of hyponatremia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Desmopressin | Phenylbutazone | |||||||
| Mechanism | Hyponatremia | Hyponatremia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hyponatremia | ||||||||
| Factor Description | Hyponatremia is a condition in which the amount of sodium in the blood is lower than normal. Symptoms of hyponatremia may include: nausea and vomiting, fatigue, headache or confusion, muscle cramps, weakness, irritability and restlessness. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised when vasopressin or desmopressin is used in combination with drugs that can cause fluid retention or SIADH. Some authorities recommend adjusting vasopressin dosage as needed. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death. | ||||||||