Drug General Information (ID: DDI809PM2A)
Drug Name			Phenyltoloxamine		Drug Info		Tuberculin purified protein derivative		Drug Info
Drug Type		Small molecule				Allergenics
Therapeutic Class		Antispasmodics				Allergy Test

Mechanism of Phenyltoloxamine-Tuberculin purified protein derivative Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Phenyltoloxamine				Tuberculin purified protein derivative
Mechanism		Antihistamine				Diagnostic skin test antigens
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Tuberculin purified protein derivative when combined with Phenyltoloxamine

Recommended Action
Management		Antihistamines should be discontinued approximately 2 to 4 days prior to skin testing procedures.

References
1	Multum Information Services, Inc. Expert Review Panel.
2	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
3	NLM. National Library of Medicine. NIH. National Institutes of Health "Trichophyton for intradermal skin testing (trichophyton mentagrophytes and trichophyton rubrum) injection.".