Drug General Information (ID: DDI7UW5EQA)
Drug Name			Enoxacin		Drug Info		Ibuprofen		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Analgesics
Structure

Mechanism of Enoxacin-Ibuprofen Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Enoxacin				Ibuprofen
Mechanism		CNS stimulant effects				CNS stimulant effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Enoxacin and Ibuprofen

Recommended Action
Management		Clinical monitoring for signs of CNS stimulation such as tremors, involuntary muscle movements, hallucinations, or seizures is recommended if fluoroquinolone antibiotics are prescribed in combination with NSAIDs.

References
1	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
2	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
3	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
4	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
5	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
6	Product Information. Penetrex (enoxacin). Rhone-Poulenc Rorer, Collegeville, PA.
7	Davey PG "Overview of drug interactions with the quinolones." J Antimicrob Chemother 22(suppl c) (1988): 97-107. [PMID: 3053579]
8	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
9	Ball P, Tillotson G "Tolerability of fluoroquinolone antibiotics: past, present and future." Drug Saf 13 (1996): 343-8. [PMID: 8652079]
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14	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.