Drug General Information (ID: DDI7S0E6FV)
  Drug Name Pramlintide Drug Info Aloe Vera Leaf Drug Info
  Drug Type Small molecule Natural product
  Therapeutic Class Antidiabetic Agents Herbal Products
  Structure

 Mechanism of Pramlintide-Aloe Vera Leaf Interaction (Severity Level: Moderate)
     Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Pramlintide Aloe Vera Leaf
      Mechanism Hypoglycemic effects Hypoglycemic effects
      Key Mechanism Factor 1
Factor Name Hypoglycemia
Factor Description Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
      Mechanism Description
  • Increased risk of hypoglycemia by the combination of Pramlintide and Aloe Vera Leaf 

Recommended Action
      Management Until more data are available, caution is advised when aloe vera is administered orally to patients receiving insulin or other antidiabetic agents due to the potential for increased risk of hypoglycemia. Patients should be monitored for changes in diabetic medication requirements.

References
1 Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS "Systemic review of herbs and dietary supplements for glycemic control in diabetes." Diabetes Care 26 (2003): 1277-94. [PMID: 12663610]
2 Tanaka M, Misawa E, Yousuke I, et al "Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds." Biol Pharm Bull 29 (2006): 1418-22. [PMID: 16819181]
3 Vogller BK "Aloe vera: a systematic review of its clinical effectiveness." Br J Gen Pract 49 (1999): 823-8. [PMID: 10885091]