Drug General Information (ID: DDI7MJUPH3)
Drug Name			Mecamylamine		Drug Info		Sodium acetate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Minerals And Electrolytes
Structure

Mechanism of Mecamylamine-Sodium acetate Interaction (Severity Level: Moderate)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Mecamylamine				Sodium acetate
Mechanism		Urine pH sensitive				Urine alkalinizer
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Mecamylamine caused by Sodium acetate mediated altered urine pH

Recommended Action
Management		Blood pressure should be closely monitored. It may be necessary to decrease mecamylamine dosage.

References
1	Allanby KD, Trounce JR "Excretion of mecamylamine after intravenous and oral administration." Br Med J 2 (1957): 1219-21. [PMID: 13472094]