Drug General Information (ID: DDI7KVRSYT)
  Drug Name Ramipril Drug Info Dalteparin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Anticoagulants
  Structure

 Mechanism of Ramipril-Dalteparin Interaction (Severity Level: Moderate)
     Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ramipril Dalteparin
      Mechanism Hyperkalemia Hyperkalemia
      Key Mechanism Factor 1
Factor Name Hyperkalemia
Factor Description Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
      Mechanism Description
  • Increased risk of hyperkalemia by the combination of Ramipril and Dalteparin 

Recommended Action
      Management Caution is advised if ACE inhibitors or ARBs are used with heparin or low molecular weight heparin. Serum potassium and renal function should be checked regularly.

References
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2 Product Information. Micardis (telmisartan). Boehringer-Ingelheim, Ridgefield, CT.
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4 Product Information. Atacand (candesartan). Astra Pharmaceuticals, Wayne, PA.
5 Product Information. Teveten (eprosartan). SmithKline Beecham, Philadelphia, PA.
6 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
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8 Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14. [PMID: 10996582]
9 Product Information. Edarbi (azilsartan). Takeda Pharmaceuticals America, Lincolnshire, IL.
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