Drug General Information (ID: DDI7KDM5IC)
Drug Name			Leuprolide		Drug Info		Capromab pendetide		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Antineoplastics				Diagnostic Agents
Structure

Mechanism of Leuprolide-Capromab pendetide Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Leuprolide				Capromab pendetide
Mechanism		Interfere with the imaging performance of Indium In 111 capromab pendetide due to the increased expression of PSMA				Indium In 111 capromab pendetide
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Capromab pendetide when combined with Leuprolide

Recommended Action
Management		Until more data are available, concomitant use of Indium In 111 capromab pendetide in patients treated with androgen ablation therapy is not recommended.

References
1	Product Information. ProstaScint (capromab pendetide). Aytu BioScience, Inc, Englewood, CO.