Drug General Information (ID: DDI7JR45XB)
Drug Name			Digoxin		Drug Info		Nisoldipine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antihypertensive Agents
Structure

Mechanism of Digoxin-Nisoldipine Interaction (Severity Level: Moderate)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Nisoldipine
Mechanism		Digoxin				Reduce the renal excretion of digoxin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Digoxin caused by Nisoldipine

Recommended Action
Management		Serum digoxin levels should be checked when clinically necessary. Patients should be advised to notify their physician if they experience signs of digoxin toxicity such as nausea, anorexia, visual changes, slow pulse, or irregular heartbeats. If digoxin toxicity is suspected, digoxin dosage should be withheld or reduced.

References
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3	Belz GG, Doering W, Munkes R, Matthews J "Interaction between digoxin and calcium antagonists and antiarrhythmic drugs." Clin Pharmacol Ther 33 (1983): 410-7. [PMID: 6831819]
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14	Sorkin E, Clissold S "Nicardipine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension, and relate." Drugs 33 (1987): 296-345. [PMID: 3297616]