Drug General Information (ID: DDI7BU82CA)
Drug Name			Norepinephrine		Drug Info		Desflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Anesthetics
Structure

Mechanism of Norepinephrine-Desflurane Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Norepinephrine				Desflurane
Mechanism		Catecholamines				Increase the arrhythmogenic effects of catecholamines
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Norepinephrine and Desflurane

Recommended Action
Management		This combination should be avoided or used very cautiously. If a halogenated anesthetic and norepinephrine must be used together, very low doses of norepinephrine concentrations are recommended and the patient's hemodynamic status should be closely monitored.

References
1	Cooke JE "Drug interactions in anesthesia." Clin Plast Surg 12 (1985): 83-9.[PMID: 2858281]
2	Smith RB "Drug interactions and drug reactions." Otolaryngol Clin North Am 14 (1981): 615-29.[PMID: 7029414]
3	Product Information. Fluothane (halothane). Wyeth-Ayerst Laboratories, Philadelphia, PA.