Drug General Information (ID: DDI74O9V5G)
Drug Name			Metolazone		Drug Info		Amphotericin B (cholesteryl sulfate)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antifungal Agents
Structure

Mechanism of Metolazone-Amphotericin B (cholesteryl sulfate) Interaction (Severity Level: Moderate)
Increased risk of hypokalemia Click to Show/Hide Mechanism Graph
Drug Name		Metolazone				Amphotericin B (cholesteryl sulfate)
Mechanism		Hypokalemia				Hypokalemia
Key Mechanism Factor 1
		Factor Name		Hypokalemia
		Factor Description		Hypokalemia is a condition in which the amount of potassium in your blood is lower than normal. If you are mildly hypokalemic, you may not have any signs or symptoms, but severe hypokalemia may have the following symptoms: fatigue, constipation, frequent or heavy urination, muscle cramps or skin tingling, muscle weakness, and a fast or irregular heartbeat.
Mechanism Description		Increased risk of hypokalemia by the combination of Metolazone and Amphotericin B (cholesteryl sulfate)

Recommended Action
Management		Patients receiving diuretics with amphotericin should be monitored closely for development of hypokalemia. Potassium supplementation may be necessary. Patients should be advised to notify their physician if they experience signs of electrolyte disturbances such as weakness, lethargy, and muscle pains or cramps.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".