Details of Drug Interaction | MecDDI

Drug General Information (ID: DDI74C930N)
Drug Name			Mecamylamine		Drug Info		Tadalafil		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Impotence Agents
Structure

Mechanism of Mecamylamine-Tadalafil Interaction (Severity Level: Minor)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name		Mecamylamine				Tadalafil
Mechanism		Hypotensive effects Neuronal acetylcholine receptor Antagonist				Hypotensive effects Prostacyclin receptor Agonist
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Prostacyclin receptor				× Structure Sequence MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
		Gene Name		PTGIR
		Uniprot ID		PI2R_HUMAN
		KEGG Pathway		hsa:5739
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Mecamylamine and Tadalafil

References
1	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
2	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.