Drug General Information (ID: DDI73KSJBA)
Drug Name			Dopamine		Drug Info		Fosphenytoin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cardiotonic Agents				Anticonvulsants
Structure

Mechanism of Dopamine-Fosphenytoin Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Dopamine				Fosphenytoin
Mechanism		Increase risk of hypotension combined with intravenous hydantoin derivative				Hydantoin derivative
Key Mechanism Factor 1
		Factor Name		Hypotensive effects
		Factor Description		Hypotension is a blood pressure reading below the prescribed limit (90/60 mmHg). Symptoms of hypotension may include: blurred or faded vision , dizziness or light-headedness, fainting , fatigue , difficulty concentrating, nausea.
Mechanism Description		Additive hypotensive effects by the combination of Dopamine and Fosphenytoin

Recommended Action
Management		Extreme caution and frequent blood pressure monitoring are recommended if concomitant use is necessary. alternative anticonvulsants may be considered.

References
1	Bivins BA, Rapp RP, Griffen WO Jr, Blouin R, Bustrack J "Dopamine-phenytoin interaction. A cause of hypotension in the critically ill." Arch Surg 113 (1978): 245-9. [PMID: 637689]
2	Cerner Multum, Inc. "Australian Product Information.".
3	Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH "Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects." J Clin Invest 63 (1979): 310-7. [PMID: 34629]